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Head and Neck Cancer Pipeline Report: Inactive Products Analysis (Dormant and Terminated) along with the reasons for Dormancy and Discontinuation

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Head and Neck Cancer Pipeline Report: Inactive Products Analysis (Dormant and Terminated) along with the reasons for Dormancy and Discontinuation

March 10
06:28 2023
Head and Neck Cancer Pipeline Report: Inactive Products Analysis (Dormant and Terminated) along with the reasons for Dormancy and Discontinuation

DelveInsight’s, “Head and Neck cancer Pipeline Insight 2023” report provides comprehensive insights about 150+ companies and 150+ pipeline drugs in the Head and Neck cancer pipeline landscape. It covers the Head and Neck cancer pipeline drug profiles, including Head and Neck cancer clinical trials and nonclinical stage products. It also covers the Head and Neck cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

For Head and Neck cancer Emerging drugs, the Head and Neck cancer pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The Head and Neck cancer pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

 

In the Head and Neck cancer Pipeline Report, a detailed description of the drug is given which includes the mechanism of action of the drug, Head and Neck cancer clinical trials studies, Head and Neck cancer NDA approvals (if any), and product development activities comprising the technology, Head and Neck cancer collaborations, licensing, mergers and acquisition, funding, designations, and other product-related details.

 

Key takeaways from the Head and Neck cancer Pipeline Report

 

  • DelveInsight’s Head and Neck cancer Pipeline report depicts a robust space with 150+ active players working to develop 150+ pipeline therapies for Head and Neck cancer.

 

  • The leading Head and Neck Cancer Companies such as Innate Pharma, GlaxoSmithKline, Debiopharm, Checkpoint Therapeutics, Quadriga BioSciences, Palleon Pharmaceuticals, Klus Pharma, Bicycle Therapeutics, CSPC ZhongQi Pharmaceutical Technology, Memgen, I-Mab Biopharma, Intensity Therapeutics, Wellmaker Bio, SN BioScience, Carisma Therapeutics, Genentech, Pionyr Immunotherapeutics, Palleon Pharmaceuticals, SN BioScience, Bicycle Therapeutics, Inhibrx, Celldex Therapeutics, Carisma Therapeutics Inc, BioAtla, Jacobio Pharmaceuticals, Compugen, GeoVax, CytomX Therapeutics, PNP Therapeutics, Galectin Therapeutics, Cyteir Therapeutics, Merck KGaA, Boehringer Ingelheim, Transgene, iTeos Therapeutics SA,  IntraGel Therapeutics, Incyte Corporation, Cue Biopharma, Rubius Therapeutics, Alkermes, Corregene Biotechnology, NanoCarrier, Kura Oncology, Betta Pharmaceuticals, Arcus Biosciences, Taiho Pharmaceutical, Astex Pharmaceuticals, Bayer HealthCare, Roche, Vaccinex, Pfizer, BioNTech,  Purple Biotech, Novartis Oncology, Macrogenics, Aveta Biomics, Cellectar Biosciences, Nanobiotix, Nektar Therapeutics, Istari Oncology, Nanobiotix, Aspyrian Therapeutics, and others.

 

  • Promising Head and Neck Cancer Pipeline Therapies such as Niraparib, Xevinapant, , CK-301, QBS10072S, A166, E-602, BT5528, RAPA-201, Mitoxantrone Hydrochloride, MEM-288, TJ004309, SNB-101, INT230-6, CT-0508, WM-S1-030, CDX-1140, PY159, MCLA-129, INBRX-106, Autogene cevumeran, JAB-3068, CAB-ROR2-ADC, CX-2029, Ad/PNP, COM701, Eftilagimod alpha, CYT-0851, GR-MD-02, TG4050, BI 765063, TumoCure, EOS-448, Epacadostat, RTX-321, CUE-101, ALKS 4230, CRTE7A2-01, NC-6004, Tipifarnib, MCLA-129, Zimberelimab, HLX10 Plus HLX07, Tolinapant, BAY1905254, OSI-774, VX15/2503, Palbociclib, Olaparib, NT219, BNT113, Buparlisib, Retifanlimab, Avelumab, APG-157, CLR 131, NBTXR3, Evorpacept, Dostarlimab, NKTR-214, IK-175, Lerapolturev, NBTXR3, Gedeptin, RM-1995, Atezolizumab and others.

 

  • The Head and Neck Cancer Companies and academics that are working to assess challenges and seek opportunities that could influence Head and Neck cancer R&D. The Head and Neck Cancer pipeline therapies under development are focused on novel approaches to treat/improve the disease condition.

  

Request a sample and discover the recent breakthroughs happening in the Head and Neck cancer Pipeline landscape @ Head and Neck cancer Pipeline Outlook Report

 

Head and Neck Cancer Overview

Head and neck cancer is a collective term that includes several different types of cancers. Cancers of the head and neck are categorized by the area in which they begin. This includes the mouth (oral cavity), throat (pharynx), voice box (larynx), sinuses and nose cavity, and salivary glands. The most common type of head and neck cancer is squamous cell carcinoma of the head and neck (HNSCCA).

 

Recent Developmental Activities of Head and Neck Cancer Treatment Landscape

 

  • In September 2022, NANOBIOTIX announced randomization of the first patient in Asia in NANORAY-312, a global Phase III registrational trial evaluating NBTXR3 for the treatment of elderly patients with locally advanced head and neck squamous cell carcinoma who are ineligible for platinum-based chemotherapy.

 

  • In August 2022, Genexine announced the dosing of the first patient in Phase II clinical trial using triple combination therapy in patients with recurrent/metastatic HNSCC. The combination therapy consists of two of Genexine’s proprietary drugs, GX-188E (a first-in-class therapeutic DNA vaccine), GX-I7 (a first-in-class long-acting interleukin 7), and Opdivo (nivolumab), a marketed PD-1 immune checkpoint inhibitor.

 

  • In May 2022, Calliditas announced that it had initiated Phase II head and neck cancer therapy trial. The trial will analyze the impact of setanaxib plus pembrolizumab in patients with CAF-density tumors. Calliditas Therapeutics has randomized the first subject in the proof-of-concept Phase II clinical trial of setanaxib (GKT831) in individuals with squamous cell carcinoma of the head and neck (SCCHN).

 

  • In May 2022, Exelixis announced results from a phase II, the investigator-sponsored trial of cabozantinib (CABOMETYX®) in combination with pembrolizumab in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). The trial met its primary endpoint of objective response rate per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 at 54%. The overall clinical benefit rate was 91%. At a median follow-up of 10.6 months, the one-year progression-free survival rate was 54.0% (95% confidence interval [CI]: 31.5-72.0%), and median progression-free survival was 14.6 months. The one-year overall survival (OS) rate was 68.4% (95% CI: 45.1-83.5%; median OS: 22.3 months).

 

  • In January 2022, The FDA accepted an investigational new drug application for the photoimmunotherapy treatment, RM-1995, for patients with advanced cutaneous squamous cell carcinoma or head and neck squamous cell carcinoma.

 

  • In February 2021, The Food and Drug Administration (FDA) granted Breakthrough Therapy designation to tipifarnib for the treatment of patients with recurrent or metastatic HRAS mutant head and neck squamous cell carcinoma with variant allele frequency greater than or equal to 20% after disease progression on platinum-based chemotherapy. 

 

For further information, refer to the detailed Head and Neck cancer Drugs Launch, Head and Neck cancer Developmental Activities, and Head and Neck cancer News, click here for Head and Neck cancer Ongoing Clinical Trial Analysis

 

Head and Neck cancer Emerging Drugs Profile

 

  • Monalizumab: Innate Pharma

Monalizumab (IPH2201) is a potentially first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells. NKG2A is an inhibitory checkpoint receptor for HLA-E. By expressing HLA-E, cancer cells can protect themselves from killing by NKG2A+ immune cells. HLA-E is frequently overexpressed on cancer cells of many solid tumors and hematological malignancies. Monalizumab may re-establish a broad anti-tumor response mediated by NK and T cells, and may enhance the cytotoxic potential of other therapeutic antibodies. Monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response. Currently, it is in Phase III stage of clinical trial evaluation to treat Squamous Cell Carcinoma of the Head and Neck.

 

  • Niraparib: GlaxoSmithKline

Niraparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP-1 and PARP-2, which play a role in DNA repair. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death. Increased niraparib-induced cytotoxicity was observed in tumor cell lines with or without deficiencies in BRCA1/2. Niraparib decreased tumor growth in mouse xenograft models of human cancer cell lines with deficiencies in BRCA1/2 and in human patient-derived xenograft tumor models with homologous recombination deficiency that had either mutated or wild type BRCA1/2.

 

  • Xevinapant: Debiopharm

Xevinapant (Debio 1143) is a potential first-in-class potent oral antagonist of IAPs (Inhibitor of Apoptosis Proteins). In preclinical studies, xevinapant restores sensitivity to apoptosis in cancer cells, thereby depriving them of one of their major resistance mechanisms. As the most clinically advanced IAP antagonist, xevinapant has established proof of efficacy in combination with chemoradiotherapy (CRT) in patients with high-risk locally advanced squamous cell carcinoma of the head and neck (LA SCCHN), with a clinically significant and sustained clinical benefit compared with CRT alone.

 

  • Enoblituzumab: MacroGenics

Enoblituzumab is an investigational monoclonal antibody that targets B7-H3 and has been enhanced using MacroGenics’ Fc Optimization platform. B7-H3 is a protein in the B7 family of immune regulator proteins. B7-H3 is widely expressed by a number of different tumor types and may play a key role in regulating the immune response to various types of cancer. MacroGenics is collaborating on the development and commercialization of enoblituzumab with I-Mab Biopharma in Greater China. MacroGenics retains full development and commercialization rights in all other territories. Currently, it is in Phase II stage of clinical trial evaluation to treat Head and Neck cancer.

 

Head and Neck Cancer Pipeline Therapeutics Assessment

There are approx. 150+ key companies which are developing the therapies for Head and Neck cancer. The companies which have their Head and Neck cancer drug candidates in the most advanced stage, i.e. phase III include, Innate Pharma.

 

Find out more about the Head and Neck cancer Pipeline Segmentation, Therapeutics Assessment, and Head and Neck cancer Emerging Drugs @ Head and Neck cancer Treatment Landscape

 

Scope of the Head and Neck Cancer Pipeline Report

 

  • Coverage- Global

 

  • Head and Neck Cancer Companies-  Innate Pharma, GlaxoSmithKline, Debiopharm, Checkpoint Therapeutics, Quadriga BioSciences, Palleon Pharmaceuticals, Klus Pharma, Bicycle Therapeutics, CSPC ZhongQi Pharmaceutical Technology, Memgen, I-Mab Biopharma, Intensity Therapeutics, Wellmaker Bio, SN BioScience, Carisma Therapeutics, Genentech, Pionyr Immunotherapeutics, Palleon Pharmaceuticals, SN BioScience, Bicycle Therapeutics, Inhibrx, Celldex Therapeutics, Carisma Therapeutics Inc, BioAtla, Jacobio Pharmaceuticals, Compugen, GeoVax, CytomX Therapeutics, PNP Therapeutics, Galectin Therapeutics, Cyteir Therapeutics, Merck KGaA, Boehringer Ingelheim, Transgene, iTeos Therapeutics SA,  IntraGel Therapeutics, Incyte Corporation, Cue Biopharma, Rubius Therapeutics, Alkermes, Corregene Biotechnology, NanoCarrier, Kura Oncology, Betta Pharmaceuticals, Arcus Biosciences, Taiho Pharmaceutical, Astex Pharmaceuticals, Bayer HealthCare, Roche, Vaccinex, Pfizer, BioNTech,  Purple Biotech, Novartis Oncology, Macrogenics, Aveta Biomics, Cellectar Biosciences, Nanobiotix, Nektar Therapeutics, Istari Oncology, Nanobiotix, Aspyrian Therapeutics, and others

 

  • Head and Neck Cancer Pipeline Therapies- Niraparib, Xevinapant, , CK-301, QBS10072S, A166, E-602, BT5528, RAPA-201, Mitoxantrone Hydrochloride, MEM-288, TJ004309, SNB-101, INT230-6, CT-0508, WM-S1-030, CDX-1140, PY159, MCLA-129, INBRX-106, Autogene cevumeran, JAB-3068, CAB-ROR2-ADC, CX-2029, Ad/PNP, COM701, Eftilagimod alpha, CYT-0851, GR-MD-02, TG4050, BI 765063, TumoCure, EOS-448, Epacadostat, RTX-321, CUE-101, ALKS 4230, CRTE7A2-01, NC-6004, Tipifarnib, MCLA-129, Zimberelimab, HLX10 Plus HLX07, Tolinapant, BAY1905254, OSI-774, VX15/2503, Palbociclib, Olaparib, NT219, BNT113, Buparlisib, Retifanlimab, Avelumab, APG-157, CLR 131, NBTXR3, Evorpacept, Dostarlimab, NKTR-214, IK-175, Lerapolturev, NBTXR3, Gedeptin, RM-1995, Atezolizumab, and others.

 

  • Head and Neck cancer Pipeline Segmentation: Product Type, Molecule Type, Mechanism of Action, Route of Administration 

 

Dive deep into rich insights for drugs for Head and Neck cancer Pipeline Companies and Therapies, click here @ Head and Neck cancer Unmet Needs and Analyst Views

 

Table of Content

  1. Introduction
  2. Executive Summary
  3. Pipeline Therapeutics
  4. Therapeutic Assessment
  5. Head and Neck cancer – DelveInsight’s Analytical Perspective
  6. Late Stage Products (Phase III)
  7. Monalizumab: Innate Pharma
  8. Drug profiles in the detailed report…..
  9. Mid Stage Products (Phase II)
  10. Enoblituzumab: MacroGenics
  11. Drug profiles in the detailed report…..
  12. Early Stage Products (Phase I)
  13. IK-175: Ikena Oncology
  14. Drug profiles in the detailed report…..
  15. Preclinical and Discovery Stage Products
  16. Research programme: cancer vaccines – Voltron Therapeutics
  17. Drug profiles in the detailed report…..
  18. Inactive Products
  19. Head and Neck cancer Key Companies
  20. Head and Neck cancer Key Products
  21. Head and Neck cancer- Unmet Needs
  22. Head and Neck cancer- Market Drivers and Barriers
  23. Head and Neck cancer- Future Perspectives and Conclusion
  24. Head and Neck cancer Analyst Views
  25. Head and Neck cancer Key Companies
  26. Appendix

 

Got Queries? Find out the related information on Head and Neck cancer Mergers and acquisitions, Head and Neck cancer Licensing Activities @ Head and Neck cancer Recent Trends, and Future Perspectives

 

 

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